FDA Approved :

There are 3 main self application cream to this date, They are mainly prescribed for self application and doctors will provide the instruction how they be used. Preference of their usage from physician to another physician is different.

Aldara ® (Imiquimod)

It seems it is the  most commonly used self application cream based on my experience in my practice. Perhaps because of 2 main following reasons:
1)It is the very first wart treatment cream in the market.
2) It is easier for clinician to write prescription than physical removal.

It cause a lot of redness, ulceration, induration and irritation. To my personal opinion this cream is not as effective as clinician / patient may  assume.

It weaken the diaphragm and latex condom and causing it rupture, should not be used in vaginal area.  No sexual contact is recommended during the treatment.
Get emergency medical help if you have any of these signs of an allergic reaction while taking imiquimod topical (the active ingredient contained in Aldara) hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Wash off the medicine and call your doctor at once if you have a serious skin reaction such as severe itching, burning, oozing, bleeding, or skin changes where the medicine is applied.
Stop using imiquimod topical and call your doctor at once if you have a serious side effect such as flu symptoms such as fever, chills, body aches, tired feeling, swollen glands.
When treating genital warts around the vagina, if you have severe swelling or urination problems, stop using imiquimod topical and call your doctor right away.
Less serious side effects of imiquimod topical may include:

  • Mild skin irritation, itching, dryness, flaking, scabbing, crusting, redness, or hardening of the skin where the medicine was applied;
  • Changes in the color of treated skin;
  • Headache, dizziness, chest pain, back pain;
  • Cold sores, fever blisters;
  • Cold symptoms such as stuffy nose, sneezing, sore throat;
  • Nausea, diarrhea, loss of appetite; or
  • Vaginal itching or discharge.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

VEREGEN® (sinecatechins)

It is a latest treatment cream that been used recently mostly by dermatologist for treatment of genital Anal warts. It is a green tea extract and been use topically of the warts for certain time. It cause a lot of irritation, redness, ulceration, and induration on treatment area. It weaken the diaphragm and latex condom and causing it rupture ,so no sexual contact during the treatment course. Based on my experience of evaluating  patients who have been using this cream, I should say this cream is not significantly effective.

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